Objective Based on the design of a novel hip prosthesis stem, the stress distribution differences during standing, walking, running and in sitting posture were analyzed. Methods Based on human CT data,seven groups of hips joint models implanted with different stems were established, and stresses of the prosthetic stem and femur under different working conditions were calculated by using the finite element analysis method.Results Compared with the traditional prosthetic stem, the peak stress of the novel prosthetic stem during standing was reduced by 23% , and the femoral stress was reduced by 72%. The results of seven models showed that the prosthetic stem with the height of 86. 5 mm was the most suitable for patients’ needs. The multi-working condition results showed that when the patient was in sitting posture, the stem had the least stress and a longer service life. Conclusions The novel prosthetic stem helps to prolong the life of the prosthesis and reduce the risk of bone damage. This hip prosthesis model provides scientific theoretical support for post-design of the stem and postoperative rehabilitation of patients.