Objective To study the effects of different hole sizes on implantable collamer lens ( ICL) deformation and flow field in anterior chamber. Methods From the perspective of the combination of medicine and engineering, the fluid-structure coupling numerical simulation method was adopted to study the influence of different hole sizes of ICL on its deformation and intraocular aqueous humor flow field ( mass flow, velocity, pressure and temperature). Results In terms of fluid dynamics, the hole sizes for aqueous humor flowing through the central hole of ICL from large to small was 0. 36, 0. 40, 0. 30, 0. 20, 0. 10 mm, respectively, and such flow showed a nonlinear relationship with hole sizes. The pressure of posterior chamber was slightly higher than that of anterior chamber, and the pressure difference between anterior and posterior chambers graduallydecreased with the increase of hole sizes. The temperature distribution in the eye was not sensitive to the effect of hole sizes. In terms of solid statics, the ICL with the diameter of 0. 36 mm had the smallest deformation, and its deformation was dominated by the flow of aqueous humor through the central hole. The larger the flow rate, the smaller the ICL deformation. Conclusions Through comprehensive analysis of fluid dynamics and solid statics, this study verified the rationality of the existing 0. 36 mm hole size, and proposed that an ideal hole size range should be d≥0. 36 mm. The results are helpful to explore the failure mechanism of ICL, improve the success rate of clinical surgery, and provide experience for ICL localization in the future.