服用非变性Ⅱ型胶原蛋白对骨性膝关节炎患者膝关节活动度的影响
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国家高技术研究发展计划(863计划)(2014AA022109)


Influences of Oral Undenatured Collagen Type Ⅱ on Knee Joint Range of Motion in Patients with Knee Osteoarthritis
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    摘要:

    目的 通过步态分析评估口服非变性Ⅱ型胶原蛋白对膝关节骨性关节炎的康复效果。方法 受试者为16位Ⅰ、Ⅱ级膝关节骨性关节炎患者,以WOMAC问卷了解患者膝关节的不适症状,使用KneeKG红外线三维膝关节评估系统分析患者患肢膝关节的运动学特征,通过配对t检验分析服用非变性Ⅱ型胶原蛋白3个月后的运动学数据差异。结果 服用非变性Ⅱ型胶原蛋白后,患者膝关节疼痛感、僵硬感、日常生活困难度皆明显降低(P<0.05),膝关节屈伸角度由51.8°±15.2°增加至58.4°±10.7°(P<0.05),着地时膝关节内翻角度降低至2.1°±4.8°,膝关节内翻症状的改善率达82%。结论 服用非变性Ⅱ型胶原蛋白3个月对膝关节骨性关节炎患者起到康复作用,膝关节活动角度接近健康老年人水平,同时改善了膝内翻的症状。

    Abstract:

    Objective To evaluate the effects of oral undenatured collagen type Ⅱ on rehabilitation of knee osteoarthritis. Methods Sixteen patients with levelⅠand Ⅱ knee osteoarthritis (KOA) were recruited in this study. The WOMAC questionnaire was used to measure the symptoms of knee joint in patients. The KneeKG 3D evaluation system was used to measure the kinematics characteristics of the knee joints. The pair t-test was applied to analyze the differences in knee kinematics after taking undenatured collagen type Ⅱ for 3 months. Results After taking undenatured collagen type Ⅱ, the patient’s feeling of knee joint pain, stiffness, and the difficulty of daily life was reduced. In addition, the knee flexion angle increased from 51.8°±15.2° to 58.4°±10.7° (P<0.05), and the knee varus angle decreased to 2.1°±4.8°. The improvement rate of knee varus was 82%. Conclusions Taking undenatured collagen type Ⅱ for 3 months could play a role in rehabilitation for patients with early KOA. The knee range of motion was close to the level of healthy elderly people, thus improving the symptoms of knee varus.

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陈佑,罗宇婷,王海燕,陈泽阳,李旭鸿,徐玉明.服用非变性Ⅱ型胶原蛋白对骨性膝关节炎患者膝关节活动度的影响[J].医用生物力学,2020,35(3):372-377

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  • 收稿日期:2019-03-07
  • 最后修改日期:2019-06-19
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  • 在线发布日期: 2020-06-24
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