应力对新型镁合金骨钉体外降解速率影响的实验研究
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河南省科技攻关项目(162102310366)


Experimental Study of Stress Effects on the Degradation Rate in vitro of Novel Magnesium Alloy Bone Screws
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    摘要:

    目的 研究应力对新型镁合金骨钉体外降解速率的影响。方法 根据逆向建模方法建立胫骨骨折三维模型设计体外降解实验装置,用有限元计算得到的骨钉应力分布加载实验载荷,有效提高实验的准确性及效率。实验共分为4组,A组作为对照组不加力,B、C和D组分别施加150、250、350 N轴向压力,研究不同力学环境对骨钉体外降解速率的影响程度。将应力分布与体外降解实验结果结合,得到应力与新型镁合金骨钉体外降解速率的变化曲线。结果 体外降解实验表明,A组失重最小,产生氢气最少,平均降解速率为(0.315±0.005) mm/年;有应力组随着施加载荷的增大,失重、产氢量逐渐增加,B、C、D组平均降解速率分别为(0.379±0.006)、(0.469±0.007)、(0.547±0.009) mm/年。结论 新型镁合金骨钉在力学环境中进行降解时,骨钉所受的应力越大,其降解速率越快;得到新型镁合金骨钉所受的最大应力与平均体外降解速率之间的关系曲线,为镁合金骨钉的选材、设计及临床应用提供数据支撑和理论指导。

    Abstract:

    Objective To study the effect of stress on the degradation rate in vitro of novel magnesium alloy bone screw. Methods A three-dimensional (3D) model of the tibia fracture was established using the reverse engineering method. Then, based on the FE model, the in vitro degradation experimental device for bone screws was designed. The stress distribution of the screw by finite element calculation was used as the in vitro experimental load, which effectively improved the accuracy and efficiency of the experiment. The experimental samples were divided into four groups. Group A was treated as control group without force application, while Groups B, C and D were subjected to 150, 250 and 350 N axial forces. The influence of different mechanical environment on the degradation rate in vitro of bone screws was investigated. Finally, combining the stress distributions with the degradation experiment results in vitro, the curve between the stress and the degradation rate in vitro of novel magnesium alloy bone screws was obtained. Results Degradation experiments in vitro showed that Group A had the lowest weight loss and hydrogen production, and the average degradation rate was (0.315±0.005) mm/a. While in the stress groups, the weight loss and hydrogen production increased gradually with the axial force increasing. The average degradation rates of Groups B, C and D were (0.379±0.006), (0.469±0.007) and (0.547±0.009) mm/a, respectively. Conclusions When the novel magnesium alloy bone screw was degraded in mechanical environment, the greater stress on the screw would cause the faster degradation rate in vitro. The obtained relationship between the maximum stress and the average degradation rate in vitro of the novel megnesium alloy bone screw provided data support and theoretical guidance for material selection, design and clinical application of magnesium alloy bone screws.

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马晓孟,胡志刚,祖向阳,王新征,杜喆.应力对新型镁合金骨钉体外降解速率影响的实验研究[J].医用生物力学,2020,35(1):77-82

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  • 收稿日期:2019-03-11
  • 最后修改日期:2019-03-21
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  • 在线发布日期: 2020-03-03
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