定向拉伸工艺对可吸收肩袖补片力学性能的影响
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国家科技计划(国家重点研发计划)(210YBXM2016110002)


Influences of Unidirectional Stretching Process on Mechanical Properties of Absorbable Patch for Rotator Cuff Repair
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    摘要:

    目的 研究定向拉伸工艺对不同可吸收补片力学性能的影响,评价其作为肩袖损伤修复补片的潜力。方法 采用定向拉伸工艺制备聚乳酸基材料的可吸收补片,设定不同的定向拉伸温度(50~80 ℃)和拉伸比(0.5~4.3),研究不同参数对不同材料可吸收补片力学性能的影响,同时对其热性能、结晶性能和表面形貌进行表征。结果 定向拉伸温度和拉伸比可以调控可吸收补片的拉伸强度和拉伸应变、热性能、结晶性能和微观形貌。当拉伸温度分别为60、70、70 ℃,对应的拉伸比分别为3、3、4.3时,聚-L-丙交酯-乙交酯的共聚物(PLGA)、 聚-L-丙交酯-D,L-丙交酯的共聚物(PLDLLA)、聚-L-丙交酯-ε-己内酯的共聚物(PLC)最大拉伸强度分别为(74±7)、(97±6)、(107±8) MPa,大于犬类冈下肌腱的力学强度(40 MPa),但仅有PLDLLA补片的应变满足天然肩袖的柔韧性。结论 定向拉伸工艺可以提高可吸收补片的力学性能,PLDLLA补片具有增强肩袖撕裂的潜力。

    Abstract:

    Objective To investigate the effect of unidirectional stretching on mechanical properties of different absorbable patches and evaluate its potential as a patch for rotator cuff repair. Methods The unidirectional stretching process was used to prepare absorbable patches with different polylactide based materials. Different unidirectional stretching temperatures (50-80 ℃) and stretching ratios (0.5-4.3) were set. The effects of different parameters on mechanical properties of the absorbable patches with different materials were studied. Their thermal properties, crystallization and surface morphology were characterized. Results The unidirectional stretching temperature and stretching ratio could adjust the tensile strength and strain, thermal property, crystalization and surface morphology of the absorbable patch. At directional stretching temperatures of 60, 70, 70 ℃ and stretching ratios of 3, 3, 4.3, respectively, the absorbable patches made of poly-L-lactide-co-glycolide (PLGA), poly-L-co-D, L-lactide (PLDLLA) and poly-L-lactide-co-ε-caprolactone (PLC) had the maximum tensile strength (74±7),(97±6), (107±8) MPa, which were larger than the tensile strength for infraspinatus tendon of canine (40 MPa). However, only the strain of PLDLLA patch conformed to the flexibility of natural rotator cuff. Conclusions The unidirectional stretching process can improve mechanical properties of the absorbable patch. The absorbable patch made of PLDLLA has the potential to reinforce the rotator cuff tear.

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曹晓艳,方宁,田娜,董骧,郑诚功.定向拉伸工艺对可吸收肩袖补片力学性能的影响[J].医用生物力学,2020,35(1):27-34

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  • 收稿日期:2019-03-19
  • 最后修改日期:2019-04-29
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  • 在线发布日期: 2020-03-03
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