刘丽娟,索文超.急性呼吸窘迫综合征患者下呼吸道内气流运动特性[J].医用生物力学,2019,34(5):460-467
急性呼吸窘迫综合征患者下呼吸道内气流运动特性
Characteristics of Airflow in Lower Respiratory Tract of ARDS Patients
投稿时间:2018-10-10  修订日期:2018-11-25
DOI:
中文关键词:  急性呼吸窘迫综合征  下呼吸道  计算流体动力学  气流  数值模拟
英文关键词:acute respiratory distress syndrome (ARDS)  lower respiratory tract  computational fluid dynamics (CFD)  airflow  numerical simulation
基金项目:
作者单位
刘丽娟 首都医科大学附属北京电力医院 呼吸内科 
索文超 陆军航空兵学院 航空机械工程系 
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中文摘要:
      目的 应用计算流体动力学(computational fluid dynamics, CFD)技术对急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者不同程度呼吸窘迫状态时下呼吸道内气流运动特性进行模拟研究。方法 基于CT影像数据建立真实健康人体下呼吸道三维模型。采用标准k-ε湍流模型对下呼吸道内的气体流动进行数值模拟,分析下呼吸道内气流的速度、流量、压力以及壁面剪切应力等参数分布特点。结果 拟合下呼吸道空气流动阻力与呼吸强度的函数关系;得到下呼吸道内空气流速、压力、壁面剪切应力的分布特点以及空气流量在各肺及各叶支气管的分配情况。结论 通过CFD模拟分析可以获得更为详细的下呼吸道流场相关数据,为ARDS患者的临床治疗提供理论依据。
英文摘要:
      Objective To study the airflow characteristics in lower respiratory tract of acute respiratory distress syndrome (ARDS) patients with different degrees of respiratory distress by using computational fluid dynamics (CFD) technology. Methods Three-dimensional model of lower respiratory tract from a healthy subject was established based on CT image data. Standard k-ε turbulence model was used to simulate the airflow in lower respiratory tract, and the distribution characteristics of air velocity, airflow rate, air pressure and wall shear stress (WSS) in lower respiratory tract were analyzed. Results The function relationship between the pressure drop of airflow in lower respiratory tract and the respiratory intensity was fitted. The distribution characteristics of air velocity, air pressure and WSS in lower respiratory tract were obtained, and the airflow distributions in the lungs and the bronchi of each lobe were also obtained. Conclusions More detailed data of lower respiratory airflow field can be obtained by CFD simulation analysis, which provides the theoretical basis for clinical treatment of ARDS patients.
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