党航宇,胥义.基于CT图像三维重建支气管内气体流动特性[J].医用生物力学,2019,34(5):453-459
基于CT图像三维重建支气管内气体流动特性
The Airflow Characteristics in a 3D Airway Model Based on CT Images
投稿时间:2018-10-09  修订日期:2018-12-03
DOI:
中文关键词:  支气管  三维重建  无心跳供体  被动呼吸  数值模拟
英文关键词:airway  three-dimensional reconstruction  non-heart-beating donor (NHBD)  passive breathing  numerical simulation
基金项目:国家自然科学基金项目(51576132)
作者单位
党航宇 上海理工大学 生物系统热科学研究所 
胥义 上海理工大学 生物系统热科学研究所 
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中文摘要:
      目的 探讨低温气体在肺支气管内部的传质机理,为制定低温通气冷却无心跳供体肺方案提供理论依据。方法 基于人体肺部CT图像三维重建得到真实支气管模型,并采用计算流体动力学方法 研究往复式通气过程中不同通气频率(0.5、0.25、0.125 Hz)条件下支气管内不同区域的流动分布特点。结果 往复式通气过程中真实支气管内流动呈现出复杂的三维流动特征,且吸气和呼气过程中支气管不同区域的流动结构各不相同;真实支气管不规则的几何结构会对其内部流动产生重要影响;通气频率从0.5 Hz逐渐减小到0.125 Hz过程中,支气管不同区域边界层厚度逐渐增大,同时高速主流也得到不同程度增强。结论 相比理想圆管模型,基于CT三维重建得到的支气管模型能够更加准确反映支气管内部流动结构。研究结果 对于无心跳供体肺低温通气冷却技术的优化具有重要指导意义。
英文摘要:
      Objective To discuss the mass transfer of low temperature gas in the lung bronchus, so as to provide a theoretical basis for the implementation of hypothermic ventilation cooling non-heart-beating donor (NHBD) lung program. Methods A real airway model was reconstructed based on human lung CT images, and the computational fluid dynamics (CFD) method was used to investigate the airflow characteristics inside the airway during reciprocating ventilation. The effect of ventilation frequency (0.5, 0.25, 0.125 Hz) on bronchial flow was also studied. Results The flow in the airway showed complex three-dimensional (3D) flow characteristics during reciprocating ventilation. The flow in different areas of the airway was different during inhaling and exhaling; the irregular bronchial geometry had an important effect on its internal flow; when the ventilation frequency decreased from 0.5 Hz to 0.125 Hz, the thickness of flow boundary layer would increase, and the mainstream velocity in different areas of the airway was enhanced to different degrees. Conclusions The real airway model based on CT 3D reconstruction was more accurate than the ideal circularity tube model in showing the bronchial flow. The research findings have an important guiding significance to optimize the hypothermic ventilation cooling NHBD lung technique.
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