基于3D打印多孔支架和植入体的结构设计研究进展
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国家自然科学基金项目(11322223,81471753),国家重点研发计划课题(2016YFB1101102),北京市青年骨干项目(2017000026825G280)


Research Progress in Structural Design of Porous Scaffolds and Implants Based on 3D Printing
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    摘要:

    支架或植入体的弹性模量过高会产生应力遮挡效应,引发骨吸收以及后期支架或植入体松动等问题。多孔支架和植入体可以根据需要调整其孔隙率和弹性模量,从而减小应力遮挡,同时多孔结构有利于骨组织的长入,利于骨整合。分别介绍3D打印多孔支架和植入体3种基本结构(均匀多孔结构、类骨小梁结构和功能梯度结构)的设计方法,以及基于计算机辅助设计、隐式曲面、图像、拓扑优化的设计方法,为解决应力遮挡问题和设计3D打印多孔支架和植入体提供参考建议。

    Abstract:

    The high elastic modulus of scaffolds or implants will result in stress shielding effect, which may lead to bone resorption and scaffold or implant loosening in the late stage. Porous scaffolds and implants can adjust their porosity and elastic modulus according to the mechanical environment, thereby reducing stress shielding; meanwhile, porous structures are beneficial to bone tissue growth, which is conducive to osseointegration. Three kinds of basic structure for porous scaffolds and implants by 3D printing were summarized, namely, uniform porous structure, bone-like trabecular structure and functionally graded structure. The design methods of these structures were introduced respectively, including computer-aided design (CAD)-based, implicit surface-based, image-based and topology optimization-based design method, so as to provide references for solving the stress shielding problem, as well as designing porous scaffolds and implants.

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赵春伶,贾少薇,李剑,张睿,宫赫.基于3D打印多孔支架和植入体的结构设计研究进展[J].医用生物力学,2019,34(4):446-452

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  • 收稿日期:2018-04-15
  • 最后修改日期:2018-05-26
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  • 在线发布日期: 2019-08-28
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