杜静珂,于志锋.机体衰老对骨细胞力学响应的影响[J].医用生物力学,2019,34(3):333-338
机体衰老对骨细胞力学响应的影响
Effects of Senescence on Mechanical Response of Osteocyte
投稿时间:2019-04-08  修订日期:2019-05-01
DOI:
中文关键词:  力学响应  衰老  骨细胞  骨重建
英文关键词:mechanical response  senescence  osteocyte  bone remodeling
基金项目:国家自然科学基金项目(11572197,11872251)
作者单位
杜静珂 上海交通大学医学院附属第九人民医院 骨科 上海市骨科内植物重点实验室 
于志锋 上海交通大学医学院附属第九人民医院 骨科 上海市骨科内植物重点实验室 
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中文摘要:
      骨骼是一个动态变化的器官,骨细胞的形态、结构和功能随力学刺激大小、方向、形式的不同而发生变化。适当的力学刺激是维持骨形成和骨吸收动态平衡的关键。随着年龄的增加,骨组织衰老会引起包括骨组织微环境、骨细胞形态、骨细胞内信号通路等在内的一系列变化,使骨骼力学响应能力减弱,进而引起骨质疏松等多种疾病。因此,研究衰老如何影响骨细胞的力学响应具有重要意义。重点讨论机体衰老对骨细胞力学响应的影响。
英文摘要:
      Bone is a dynamic organ, and the morphology, structure and function of bone can vary with the size, direction and form of mechanical stimulation. Appropriate mechanical stimulation is the key to maintain the dynamic balance of bone formation and bone resorption. However, with aging, the senescence of bone tissues causes a series of changes, including bone microenvironment, osteocyte morphology, signaling pathways in the osteocyte, etc., which weakens its mechanical response ability and then leads to osteoporosis and other diseases. Therefore, it is of great significance to study how aging affects the mechanical response of osteocyte. This review mainly discusses the influence of aging on mechanical response of the osteocyte.
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