郑国莹,吴旭东,隋磊.LINC复合体与细胞内机械力传导[J].医用生物力学,2019,34(3):327-332
LINC复合体与细胞内机械力传导
LINC Complex and Intracellular Mechanotransduction
投稿时间:2018-05-23  修订日期:2018-07-14
DOI:
中文关键词:  机械力传导  LINC复合体  细胞骨架
英文关键词:mechanotransduction  LINC complex  cytoskeleton
基金项目:天津市自然科学基金重点项目(16JCZDJC32800)
作者单位
郑国莹 天津医科大学 口腔医院 
吴旭东 天津医科大学, 细胞生物学系天津医学表观遗传学协同创新中心天津医学表观遗传学重点实验室 
隋磊 天津医科大学 口腔医院 
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中文摘要:
      细胞作为力学感受器,可以感知、传递施加在其表面的机械力并调整自身力学性能,维持自身稳定。机械力从细胞表面或细胞质传递到细胞核依赖于完整的细胞骨架系统,该系统包括细胞质骨架和细胞核骨架两部分,而LINC复合体则是两者实现机械连接的桥梁,因此其在细胞内机械力传导中发挥着重要作用。综述LINC复合体传导机械力的结构基础和机械力传导引起的细胞核形态、转录因子的出入核以及染色质的空间构象的改变,为进一步探讨LINC复合体在细胞机械力传导过程中的作用及其对基因表达的影响奠定基础。
英文摘要:
      As mechanoreceptors, cells can sense and transmit mechanical forces exerted on their surfaces, meanwhile adjust their own mechanical properties to maintain stability. The mechanical force is transferred from cell surface or cytoplasm to the nucleus depending on the complete cytoskeletal system. This cytoskeletal system consists of cytoplasmic skeleton and nuclear skeleton, and these two parts are connected mechanically by the LINC complex (linker of nucleoskeleton and cytoskeleton complex), which plays an important role in cellular mechanotransduction. This review discusses the basic structure of mechanical transmission part in LINC complex and the changes in the nuclear morphology, the location of transcription factor, and the spatial conformation of chromatin induced by mechanotransduction, so as to lay a foundation for further exploring the role of LINC complex in cell mechanotransduction and gene expression.
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