史小全,白临奇,孙雅洲,刘海涛.基于有限元法的骨组织工程支架力学性能分析及改进设计[J].医用生物力学,2019,34(3):262-268
基于有限元法的骨组织工程支架力学性能分析及改进设计
Mechanical Properties Analysis and Improved Design of Scaffolds for Bone Tissue Engineering Based on Finite Element Method
投稿时间:2018-04-23  修订日期:2018-07-24
DOI:
中文关键词:  骨组织工程支架  孔隙结构设计  力学性能  有限元分析
英文关键词:bone tissue engineering scaffold  pore structure design  mechanical properties  finite element analysis
基金项目:
作者单位
史小全 哈尔滨工业大学 机械制造及自动化系 
白临奇 哈尔滨工业大学 机械制造及自动化系 
孙雅洲 哈尔滨工业大学 机械制造及自动化系 
刘海涛 哈尔滨工业大学 机械制造及自动化系 
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中文摘要:
      目的 分析不同孔隙结构和孔隙率骨组织工程支架的力学性能,并对支架的孔隙结构进行改进设计使其性能提高。方法 利用SolidWorks软件进行方形孔、球形孔和圆柱形孔3种结构55%~75%孔隙率的支架建模,计算得到各结构的表面积体积比;利用ANSYS Workbench软件进行结构受力的有限元计算,得到支架结构的应力分布和等效压缩模量;根据应力分布的特点,将方形孔的支架结构改进为长方形孔隙结构和长方体单元结构两种支架。结果 随着孔隙率的增加,3种结构的表面积体积比均增大,对于相同的孔隙率,方形孔和球形孔的表面积体积比较大,圆柱形孔最小;3种结构的最大压应力总体趋势是随着孔隙率的增加而增大,对于同一孔隙率的3种结构,方形孔的最大压应力最小;3种结构的模量和孔隙率近似呈线性关系,方形孔和圆柱形孔的模量值相近;60%孔隙率的方形孔及两种改进结构应力分析表明,两种改进结构的平行于应力方向的4条棱侧壁应力可减小约15%。结论 方形孔的表面积体积比和力学性能比相同孔隙率的球形孔和圆柱形孔结构要更有优势,而改进的两种结构又可以提高方形孔的力学性能,两种改进的孔隙丰富了组织工程支架的结构,研究结果 为两种支架的临床应用提供力学依据。
英文摘要:
      Objective To analyze the mechanical properties of bone tissue engineering scaffolds with different pore structure and porosity, and improve the mechanical properties of scaffolds by changing pore structure. Methods Square pore, spherical pore and cylindrical pore with different porosities from 55% to 75% were established by SolidWorks software, and the surface-volume ratio of different structures was calculated. The stress distribution and equivalent compression modulus of different scaffolds were obtained by ANSYS Workbench software. According to the stress distribution results, the scaffold with rectangular pore structure and cuboid element structure was improved instead of square pores. Results With the increase of porosity, the surface-volume ratio of the three structures increased. For the same porosity, the surface-volume ratio of square pores and spherical pores was larger, while that of cylindrical pores was the smallest. The modulus and porosity of the three structures were approximately linear. The modulus of the square pore and the cylindrical pore were similar. The stress analysis on the square pore and two improved structures with 60% porosity showed that for the two improve structures, the wall stress on 4 edges parallel to the direction of applied stresses could be reduced by 15%. Conclusions The surface-volume ratio and mechanical property of square pores were more advantageous than spherical pores and cylindrical pores with the same porosity, and the two improved structures could improve the mechanical properties of square pores. The two improved pores enriched the structure of tissue engineering scaffolds. The research findings provide the mechanical references for their clinical application.
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