江雄,哈彤,高元明,张阔,宫赫,王丽珍,樊瑜波.镁基植入体植入兔股骨后周围骨微结构变化趋势[J].医用生物力学,2019,34(3):256-261
镁基植入体植入兔股骨后周围骨微结构变化趋势
Bone Microstructual Changes Around the Magnesium Based-Implant after Implantation in Rabbit Femur
投稿时间:2018-03-30  修订日期:2018-05-13
DOI:
中文关键词:  镁基植入体  骨钉  微结构参数
英文关键词:magnesium based-implant  bone screw  microstructural parameters
基金项目:国家自然科学基金项目(11572029, 11322223)
作者单位
江雄 北京航空航天大学 生物与医学工程学院生物力学与力生物学教育部重点实验室生物医学工程高精尖创新中心 
哈彤 北京航空航天大学 生物与医学工程学院生物力学与力生物学教育部重点实验室生物医学工程高精尖创新中心 
高元明 北京航空航天大学 生物与医学工程学院生物力学与力生物学教育部重点实验室生物医学工程高精尖创新中心 
张阔 北京大学 医学部实验动物科学部 
宫赫 北京航空航天大学 生物与医学工程学院生物力学与力生物学教育部重点实验室生物医学工程高精尖创新中心 
王丽珍 北京航空航天大学 生物与医学工程学院生物力学与力生物学教育部重点实验室生物医学工程高精尖创新中心 
樊瑜波 北京航空航天大学 生物与医学工程学院生物力学与力生物学教育部重点实验室生物医学工程高精尖创新中心
国家康复辅具研究中心 
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中文摘要:
      目的 研究镁基植入体植入兔股骨不同时间点周围骨微结构参数的变化规律。方法 将直径2 mm、长7 mm有螺纹及无螺纹的高纯镁(99.99 wt.%)钉植入兔股骨髁,对照组为钻孔组及健康组。在术后8、12、16周进行Micro-CT扫描和分析,得到各组微结构参数,包括:骨质密度(BMD)、骨体积分数(BV/TV)、骨小梁厚度(Tb.Th)、骨小梁数量(Tb.N)、骨小梁分离度(Tb.Sp)。结果 8周时无螺纹镁钉组BMD、BV/TV显著高于健康组,Tb.N显著高于钻孔组与健康组,Tb.Sp显著低于健康组;12周时有螺纹镁钉组BMD、BV/TV、Tb.N显著高于钻孔组与健康组,Tb.Th显著高于健康者,Tb.Sp显著低于钻孔组与健康组;16周时无螺纹镁钉组的BMD、BV/TV、Tb.N显著高于钻孔组与健康组,Tb.Sp显著低于钻孔组与健康组。结论 镁基植入体促使周围骨组织的BMD、BV/TV、Tb.Th、Tb.N更高,Tb.Sp更低,说明其骨整合与骨生长状况良好,镁基植入体能有效促进骨再生。研究结果 为镁基植入体的骨科临床应用提供理论依据。
英文摘要:
      Objective To study the change patterns of bone microstructural parameters around the magnesium based- implants after implantation in rabbit femur at different implantation time points. Methods The threaded and non-threaded high-purity magnesium (HP Mg, 99.99 wt.%) screws, with a 2 mm diameter and a 7 mm length, were implanted into the femoral condyle of the rabbits. The control group was the drilled and healthy group. Micro-CT scanning and analysis were performed at 8th, 12th and 16th week after operation. The obtained microstructural parameters included bone mineral density (BMD), bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp). Results At 8th week, BMD and BV/TV in non-threaded magnesium screw group were significantly higher than those in healthy group, Tb.N was significantly higher than that in drilled and healthy group, and Tb.Sp was significantly lower than that in healthy group. At 12th week, BMD, BV/TV and Tb.N in threaded magnesium screw group were significantly higher than those in drilled and healthy group, Tb.Th was significantly higher than that in healthy group, and Tb.Sp was significantly lower than that in drilled and healthy group. At 16th week, BMD, BV/TV and Tb.N in non-threaded magnesium screw group were significantly higher than those in drilled and healthy group, and Tb.Sp was significantly lower than that in drilled and healthy group. Conclusions The magnesium based-implant promoted higher BMD, BV/TV, Tb.Th, Tb.N and lower Tb.Sp of surrounding implant, indicating that osseointegration and bone growth were in good condition. Magnesium based-implant could effectively promote the regeneration of bone. The results provide a theoretical basis for the orthopedic application of magnesium based-implants in clinic.
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