目的 研究微循环负载和其他生理结构的耦合关系，以构建合理的血流动力学模型。方法 在双向流-固耦合管道模型的基础上，进一步考虑微循环负载的影响，构建具有弹性管壁的长直管和多孔介质渗流负载的模型。根据负载条件和血管壁弹性的不同计算4个算例,入口条件为瞬态单脉冲速度入口，出口条件为自由出口。结果 管道内部压力处处保持在80~120 mmHg（1 mmHg=0.133 kPa）。从静止状态开始，流场通过增加储存血液总量的方式提高舒张压，最终稳定在生理指标。血管壁弹性模量增加时，血压为65~140 mmHg；而微循环阻力增加时，血压为128~166 mmHg，微循环负载在循环系统中起到了阻碍流动并重新分配血管内压力的作用。结论 在构建血流动力学模型时，必须考虑微循环负载及其耦合效应，特别对分析高血压等循环系统疾病的致病机制有重要的临床意义。

Objective To investigate the coupling relationship between microcirculation loads and other arterial structure, so as to build a reasonable hemodynamic model. Methods Based on the two-way fluid-structure interaction hemodynamic model, a three-way fluid-structure-microcirculation load interaction hemodynamic model was built by considering the influence of microcirculation loads. Four cases were calculated according to different load and elastic modulus. The inlet condition was set as transient single pulse velocity inlet, and the outlet condition was set as free exit. Results The blood pressure always maintained within 80-120 mmHg (1 mmHg= 0.133 kPa) in the whole flow field. The diastolic pressure was finally raised to physiological blood pressure by increasing the total amount of the stored flow. With the increase of elastic modulus in vascular wall, the blood pressure maintained within 65-140 mmHg. With the increase of microcirculation resistance, the blood pressure maintained within 128-166 mmHg. Microcirculation load impeded the flow and reallocated the pressure in the artery. Conclusions It is necessary to consider the influence of microcirculation loads for construction of the hemodynamic model, which has an important clinical significance in analyzing pathogenesis of the circulatory system diseases.

高等学校博士学科点专项科研基金资助课题（20101103110001）