哮喘等慢性气道疾病中气道缩窄的生物力学模型研究最新进展
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国家自然科学基金项目(11532003)


Recent advances in modeling of airway mechanical behaviors in association with airway constrictions in asthma
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    摘要:

    虽然对于探索哮喘等气道疾病的潜在治疗方法和揭示气道系统中有趣的生物物理现象等意义重大,气道缩窄的生物力学模型研究一直是既吸引人又充满挑战的研究领域。近年来,这方面的研究呈现方兴未艾的形势,新的现象和新的研究思路不断出现。本文简要介绍这方面部分最新的研究进展,重点介绍针对哮喘气道缩窄行为,致力于解释在体气道行为的生物力学模型,尤其是不仅探讨孤立气道力学行为,而且也探讨气道间相互耦合和与周围环境耦合的气道力学模型。这些相互作用涉及气道和缠绕其上的气道平滑肌层,也涉及气道动态相互作用导致的气道-肺实质通气的空间分布形态等新颖的行为和现象。

    Abstract:

    Although it is important to explore potential treatment of chronic obstructive airway diseases such as asthma, as well as to discover interesting biophysical phenomena in airway system, the research on biomechanical models of airway narrowing remains a both appealing and challenging field. However, there have been significant advances during recent years, with number of emerging new models and new approaches. This review article briefly introduces some of the most recent work published in the literature. In particular, those work that emphasize on asthmatic airway narrowing behavior, and strive to explain the corresponding in vivo airway behaviors. More specifically, models that discuss not only individual airway behaviors, but also interactions due to coupling between airways and their surrounding structures are focused on. This includes interesting phenomena involving the airways and the smooth muscle that surrounds the airways, as well as the emergent spatial ventilation patterns due to dynamic airway interaction.

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邓林红.哮喘等慢性气道疾病中气道缩窄的生物力学模型研究最新进展[J].医用生物力学,2016,31(4):347-355

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  • 收稿日期:2016-08-02
  • 最后修改日期:2016-08-20
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  • 在线发布日期: 2016-09-20
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