Bone marrow-derived mesenchymal stem cells (MSCs) are a kind of multi-functional stem cells with self-renewal and multi-lineage differentiation potentials, which play an important role in repair and regeneration of damaged tissues. The MSCs mobilization from bone marrow and migration through peripheral circulation into injured tissues are a key function of MSCs for tissues repairing. It has been proved in resent years’studies that various mechanical and chemical factors play a significant part in regulating the directed migration of MSCs to the damaged tissue. In this paper, the effects of mechanical and chemical factors on migration of MSCs through peripheral blood circulation to the damaged tissue are reviewed, and the possibly involved molecule mechanisms are discussed, trying to further understand the mechanochemical coupling in this process, and to provide the theoretical guidance for making mechanochemistry induced efficient migration of MSCs in tissue repair in clinic.