Objective To investigate the process and method of making an individualized limited contact dynamic compression plate (LC-DCP) and template for fixing tibial fracture, as well as its preliminary effect in clinic. Methods The custom-made tibia LC-DCP and the template used in minimally invasive percutaneous plate osteosynthesis (MIPPO) surgery were developed by 3D reconstruction of CT images, computer-aided design/manufacturing (CAD/CAM) and computer numerical control (CNC) technology, and then applied in 6 patients with tibial fractures. Results The individualized tibia LC-DCP was successfully used in clinic. The average 20-month follow-up showed that all fractures were healed in 6 patients, with 5 reaching excellent and 1 reaching good standard, according to criteria of Johner-Wruhs. Conclusions The production process of such individualized plate is simple and practicable, and has the advantages of simple operation, less injury, satisfactory reduction and fixation, high healing rate, less complexity when treating tibial fracture in MIPPO surgery. Therefore, it is worth of clinical application.