Objective To introduce the structure of the self-developed design for customized hip stem prothesis and decribe its standard cross-section shape. Methods The proximal femur model was reconstructed based on a patient’s CT image with DICOM format. The rectangle borders on cross-section of the matching area of the hip stem prosthesis were created, and the cross-section contour lines in rectangle borders were formed preliminarily by using simple lines. Based on the proximal femur model, the hip stem prosthesis was verified, and made modification to match the corresponding femoral cavity of the patient through adjusting design parameters. Results The cross-section of the customized hip stem prosthesis was of standard shapes, which was convenient for the quick design of this kind of individualized prosthesis with a simple design course. The parametric design program greatly reduced the workload when designing individualized hip stem prosthesis. Conclusions The design of customized hip stem prosthesis with standard cross-section shape could help to increase the success rate of artificial hip replacement surgeries, promote the application of customized hip stem prosthesis in clinic, and further improve the life quality of patients.