Objective To propose and numerically simulate a novel stent with triangular wire cross-section so as to compare the hemodynamic effect of endovascular stents in aneurysm with circular, rectangular and triangular cross section, respectively. Methods Three aneurysm models were constructed by implanting 3 kinds of stents separately, including one with bare circular wire cross-section stent (named CM), and one with bare rectangular wire cross-section stent (named RM), and one with bare triangular cross-section stent (named TM). An unstented aneurysm model was also constructed to serve as the control (named UM). Four models were preformed with numerical simulation of fluid-structure interaction under the same boundary conditions using finite element method. Results Compared with TM and CM, RM showed lower velocity, higher flow resistance and longer turn over time, which demonstrated that the effect of blood flow pattern on three stents was decreased in the order of RM, TM, CM. RM could reduce the magnitude and fluctuation of wall shear stress (WSS) more significantly than that of TM and CM. However, the pressure rise of TM and CM was lower than that of RM. WSS distribution and deformation results indicated the possibility of aneurysm development along the distal wall was higher than that along the proximal wall, and the top of aneurysm was in the highest risk of rupture. Conclusions Three kinds of stents show differences of hemodynamics in aneurysm treatment, which provides significant references for the structural design and optimization of endovascular stent.