Objective An arterial blood pressure fitting method, based on pulse wave signal and vessel elastic chamber model, was researched and implemented to meet the requirement of continuous blood pressure (BP) measurement in health care. Methods Photoplethysmography (PPG) signal, electrocardiograph (ECG) signal and BP data of the subjects were collected by a self developed wearable physiological monitoring system. In accordance with the temporal relation between ECG and PPG signals, the equation of regression analysis on systolic BP value and pulse wave transient time (PWTT) was deduced, and the diastolic BP measurement was achieved by coefficients analysis on PPG wave and parameter calculation on blood vessel single elastic chamber model. Results The experiment results showed that the mean difference and the standard deviation of the method were （0.51±0.74) kPa［(384±5.54) mmHg］, reaching the standard (0.665±1.064) kPa［(5±8) mmHg］ proposed by Association for the Advancement of Medical Instrumentation (AAMI). Conclusions Human blood pressure can be estimated by the pulse wave signal and elastic chamber model, which provides a new method for the continuous blood pressure measurement.