Objective To investigate the influence of the location of drug release and the stent spacing on drug deposition in curved artery walls. Method 2D curved artery and strut models were employed to carry out a numerical investigation on drug deposition under different drug release surfaces or stent spacing ( 1 strut length, 3 strut lengths, 7 strut lengths ). The results were compared with those in a straight artery. Results The drug depositions produced by four different surfaces of a single strut were quite different. Compared with the curved artery, the superiority of drug release from the top surface of the straight artery was reduced, while the weakness of drug release from proximal surface was substantially increased. There was no significant change for drug release from the distal surface. The average drug concentration increased with interstrut spacing increasing, but the percentage increase was less than that in the straight artery. Concentration differences were observed between the inside and outside of the curved artery, which on the outside showed much lower. Conclusions The local flow alteration, the drug release location and the stent spacing have significant effects on drug deposition in a curved artery and the result is obviously different from that in a straight artery.