Objective To study the effect of different loading intensity and offaxis angle on changes in spatial distribution and mechanical properties of cancellous bone from femoral head by using threedimensional(3D) finite element method. Method The same size cancellous bone specimens were selected in accordance with the main pressure trabecular direction at 0°, 15°and 45° offaxis angle from 3D model of proximal femoral bone structure based on primary study. The 3D structure parameters of the specimen were calculated, then the finite element analysis was used to simulate the uniaxial compression test, and the stress and strain distribution in different model was observed. The influences of different loading intensity and off-axis angle on biomechanical properties of proximal femoral cancellous bone were investigated. Results Based on the established finite element model of cancellous bone of human femoral head, the uniaxial compression test was simulated. It was found that there were significant differences in the proportion of cancellous bone with ≥5 000μ strain in different mechanical strength or offaxis angle on cancellous bone specimens（P<0.05）. Conclusions Distribution of femoral head cancellous bone is closely related with the mechanical adaptability. The incompatibility between structure and function decreased the biomechanical properties of femoral head cancellous bone and the subsequent bone remodeling caused by repeated negative stimulus may play an important role in femoral head necrosis.