Objective The mechanical model of nonlinear blood flow in large blood vessels is developed and the propagation of nonlinear pressure wave is studied. Methods Taking the effect of large deformation, nonlinear equation of motion is established in the current configuration in terms of the constitutive equations proposed by demiray for soft biological tissues. Results Employing the reductive perturbation method the KdV equation is derived from the nonlinear partial equations governing the motion of coupled system. Conclusion It is shown from this that the system admits an accurate periodic wave solution or solitary wave solution under certain conditions.