骨能够响应外部力学载荷,在特定位置生成或吸收骨组织不但可以提高骨的力学功能效率,而且还能及时修复日常载荷下骨内产生的微裂纹,以防止骨折并延长骨骼寿命,这称为骨功能适应性。与传统实验研究方法相比,计算机数值模拟具有可控性、可行性和可预测性等优势。鉴于骨功能适应性机制研究有重要的力学生物学理论意义和骨科临床的实用价值,本文对近年来国内外骨功能适应性数值模拟的新进展作一综述。

Bone can adapt to external mechanical loading,forming or resorbing bone tissue at the specific site in order to increase the efficiency of its mechanical function.Additionally,bone has ability to repair micro-cracks timely,which occur as a result of daily loading activities,to prevent fracture and prolong bone's life.This is termed the Bone Functional Adaptation.Compared to traditional experiments,computational simulations embody many advantages in controllable,feasibility and predictability,being paid extensive attention.Because of the significance of theoretics of mechanobiology and practice of clinical medicine,the purpose of this article is to review the progress that has been made in simulating the mechanisms of bone functional adaptation.