目的对成年离体猪气管进行生物力学实验研究,评价其生物力学特性,为生物型人工气管支架的生物力学研究提供实验方法与依据。方法应用TY8000系列50-5000N伺服控制拉力试验机对成年离体猪气管作抗弯刚度、径向支撑、纵向拉伸以及残余应力、顶破强力的测试评价。结果数据显示离体猪气管环存在残余应力,50mm长气管直径压缩50%时径向支撑力约10N,气管顶破强力从咽部约180mmHg逐渐降低至隆突处约110mmHg,气管向前与左右弯曲50°时,应力分别为0.296～0.131N和0.254～0.150N。计算机描绘猪气管应力-应变曲线显示50%应变时应力很小。结论猪气管存在残余应力,内壁压力不断增高时气管膜部发生破裂。同时,猪气管具有良好的径向支撑、弯曲与拉伸性能。

Objective To investigate and evaluate the biomechanical property of adult excised porcine trachea in order to provide the experimental methods and evidence for biomedical engineering artificial trachea.Methods TY8000 servo-handle tension test machine was used to measure the biomechanical index such as bending stiffness,radial pedestal force and stress-straining of the excised porcine trachea.The residual stress and bursting strength were also evaluated.Results The results showed that residual stress was remained in the adult excised porcine trachea.The force of radial pedestal was measured to be about 10N when the diameter of trachea was compressed to 50%.The bursting strength from pharyngeal portion to eminence of the trachea gradually dropped off with the data of 180mmHg at the pharyngeal portion while 110 mmHg at the eminence.The curve of stress-straining was described to be 0.296N～0.131N、0.254N～0.150N,respectively according to the date.Conclusion The residual stress was remained in the excised porcine trachea and the membrane of the porcine trachea will disrupt as the endospore pressure increases.It shows that the excised porcine trachea has perfect radial pedestal force,bending and elongation properties.

国家自然科学基金资助项目(30672080); 江苏省卫生厅医学重大科研课题资助项目(K200410); 江苏省高校自然科学研究计划项目(04KJB320163)