Tissues and cells in the body are continuously exposed to a complex mechanical environment. Mechanical stimulations are critical to morphological, developmental and functional states of living cells. The fashion of the mechanical stimuli applied to the cells is supposed to be extremely important for the induced cell response and function. Proliferation and differentiation of bone marrow mesenchymal stem cells would be affected by mechanical stimulation. Meanwhile, the mechanical regime is extremely important, different regime may induce totally different effect. This paper focused on review in progress of the differentiation of bone mesenchymal stem cells induced by mechanical stimulation.