Objective To study the tumor-immune model under the heterogeneous blood perfusion caused by the nonhomogeneity of vessel distribution. Methods Assume the distribution of blood perfusion to be quadratic along radius axis and adapt parameters accordingly. Solve the model given by Costa et al and compare with their result. Results The tumor-immune competition various obviously among different locations. The growth stagnates in the nuclear region, but acquires monotonous or periodical uncontrolled patterns in the outer layer of the core. Restriction of the tumor growth appears in the peripheral layer of the solid tumor. Conclusion The tumor-immune competition shows palpable discrepancy when taking into account the heterogeneity of blood perfusion.