Objective To investigate the effect of physiology parameter and drug injection-methods on drug delivery in solid tumor. Methods The distributing of the tumor vascular is sphere-symmetry, and the surface areas per unite volume for blood vessels is a function of radius. The tumor interstitium is considered as porous medium and drug could pass through the microvascular into it. The drug in tumor interstitium is transported by diffusion. The interstitium of normal tissue contain vessels and lymphatic, and the drug can be absorbed by lymphatic. In the normal tissue an advanced pharmacokinetic model is considered. The area under the curve (AUC) of drug concentration which is higher than minimum effective concentration (MEC) in tumor during 24 hours is used to evaluate the treatment of drug. Results Increasing vascular permeability coefficient P and the drug diffusion coefficient D, AUC will increase. In the six injection-methods, injecting by continuing-dropping in separated time periods or bolus injection in several times with the same interval could obtain the highest AUC. Conclusion Increasing vascular permeability coefficient, raising the drug diffusion coefficient, and injecting by continuing-dropping in separated time periods or bolus injection in several times with the same interval are more useful for treatment of tumor.