灌注压变化对左冠脉血流影响的建模和仿真研究
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A Study of Blood Flows in Left Coronary Artery and Their Dependences on Perfusion Pressure with Modeling and Simulation
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    摘要:

    目的 通过对左冠状动脉的建模与仿真 ,对体外反搏提高缺血心肌灌注血流的机理进行研究。方法 根据牛顿定律和连续性方程 ,用电路分析模型来表示冠状动脉的每一小部分。通过每个部分的模拟电路模型对整个左冠状动脉进行建模。以主动脉血压的实测数据作为输入数据 ,利用Pspice软件进行仿真。 结果 仿真结果表明在体外反搏的情况下 ,左冠状动脉分支在舒张期的灌注血流得到了明显提高。结论 使用体外反搏的方法改变灌注压可以提高左冠脉血流灌注

    Abstract:

    Objective A circuit model of left coronary artery was created to analysis the theory of external counterpulstion (EECP) enhanced perfusion blood flow of ischemic myocardium. Methods From Newton's equation and the continuity equation, an equivalent analogue circuit model can be derived for each small segment of the coronary arteries. By replacing each segment with its analogue circuit model, a final model of left coronary artery can be constructed. Using Pspice simulation software, The model was simulated using experimentally measured aortic pressure. Results The model simulation shows that perfusion blood flow through left coronary artery were increased obviously with augmentations of perfusion pressure by EECP during diastolic period. Conclusion The results demonstrate that raising perfusion pressure with EECP can improve perfusion blood flow in left coronary artery.

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王东城,王怀阳,吴晓明,岑人经.灌注压变化对左冠脉血流影响的建模和仿真研究[J].医用生物力学,2004,19(1):15-18

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