Simplifying the complicated structure of the cancellous bone so as to get a regular cube-frame of geometry and utilizing the equivalent element channel a physical model which takes accounts of effects coming from the surface friction drag between fluid(such as marrow etc.) and solid medium was proposed. A relation between pressure gradient and velocity for the liquid flow through porous media was formulated. Thereby the expression predicting the permeability k of cancellous bone was derived by the cube-frame. Measurement of k has been made in a special apparatus. The results show that the theoretical predictions based on the model presented in this paper agree with the experiment values and provide corresponding data of the penetrability for the application of the mechanics behavior study about cancellous bone.