The study of anti-protruding properties of dura and substitutes is important to reconstnlction of skull defecfs. The parameters of anti-protruding properties of dura and substitutes are introduced on the basis of constant creep solution of the dural deflection under the constant intracranial pressure . Dura and Substitutes are arranged in order to the parameters: the fresh human dura is the best anti-protruding material,the lyophilized human dura is the best substitute, and artificial membrane of bovine cardiac valve, silicone rubber and terylene are unsuited to anti-protrudig materials. The measurements show that dura is isotropy approximately, but temporalis myofascia and pericranium is anisotropy.