A flow model for splenic circulation system was proposed, according to the knowledge of its circulatory characteristics. The effect of increments in splenic arterial flow(SAF) and splenic venous pressure(SVP) on splenic blood and red cell accumulation were analyzed by using the model. The results showed that an increase in SAF or SVP caused a rise in splenic size and hematocrit, concomitantly a greater accumulation of the splenic raf cell. These results were justified by the experimental study of dog spleen in vitro