应力刺激对骨质疏松性骨折愈合的影响──扫描电镜观察
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EFFECTS OF STRESS STIMULATION ON THE OSTEOPOROTIC FRACTURE HEALING AN-OBSERVATION THROUGH SCANNING ELECTRON MICROSCOPY
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    摘要:

    本研究选取30例骨质疏松症骨折股骨粗隆(间)患者,技术后是否有效地给予骨折部应力刺激随机分成两组,职活检进行扫描电镜观察,结果发现两组患者在骨折两周左右,观察结果基本相同,但在骨痂塑形改造期,有效应力刺激组骨折部骨吸收陷窝内胶原纤维形成良好,互相平行,呈束状排列,与骨小梁长轴方向一致。而在无有效应力刺激组,骨折部破骨细胞性骨吸收显得异常活跃,骨改建滞留于骨吸收向骨形成转换期,骨小梁变细,穿孔、离断,骨吸收陷窝底部光滑,很少有胶原纤维形成。研究提示,骨质疏松症骨折的治疗,不但要求很好的复位,坚强固定;而且在骨折塑形改造期,更应该给予有效的应力刺激,才能使骨质疏松骨折得以正常愈合。

    Abstract:

    In this study 32 cases of osteoporosis with intertrochanter fracture were divided into two groupsaccording to whether or not an effective stress stimulation applied on the fracture portion afteroperation. Bone cancellous specimens were taken for scanning electron microscopy. Results showed:at two weeks after fracture, the process of callus formation were similar in the two groups; but inthe remodeling stage, in the stress stimulated fracture group, collagen fibers formed well along thelong axis of trafg thin, perforaed and disconnected. The surface of cavity is smooth and few collagenfibers formed. The study indicated that in addition to good relocation and rigid fixation andeffective stress stimulation in the remodeling stage of fracture healing are essential to the treatmentof osteoporotic fracture.

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饶根云,陈一鸣,谢乐屏,陈大勇,钱世云.应力刺激对骨质疏松性骨折愈合的影响──扫描电镜观察[J].医用生物力学,1998,13(4):233-237

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