微血管网络的生物打印及生物力学功能评价
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生物力学与力生物学教育部重点实验室

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Bioprinting Fabrication and Biomechanical Functional Evaluation of Microvascular Networks
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Key Laboratory of Biomechanics and Mechanobiology Beihang University,Ministry of Education

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    摘要:

    体外构建微血管网络是重建工程组织、器官芯片模型和类器官的关键步骤,在组织工程与再生医学、药物筛选和疾病模型等多领域具有重要意义。生物打印技术作为前沿的生物制造手段,通过精确沉积生物材料、细胞和活性分子,能够构建出复杂的微血管网络,重现天然微血管的几何结构和功能特性。本文综述了生物打印微血管网络的研究进展,重点探讨生物打印技术、生物墨水以及微血管网络的生物力学功能评价。

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    Constructing functional microvascular networks in vitro represents a pivotal step in the creation of engineered tissues, organ-on-chip models, and organoids, holding profound implications for tissue engineering, regenerative medicine, drug screening, and disease modeling. As a cutting-edge bio-manufacturing approach, bioprinting enables the precise deposition of biomaterials, cells, and bioactive molecules to fabricate intricate microvascular networks that faithfully replicate the geometric architecture and functional properties of native microvasculature. This review summarizes the research progress in bioprinting microvascular networks, with a focus on bioprinting technologies, bioinks, and the biomechanical functional evaluation of microvascular networks. This review provides an overview recent advances in bioprinting microvascular networks, highlighting key developments in bioprinting technologies, bioinks and the biomechanical functional evaluation of microvascular networks.

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  • 收稿日期:2025-02-11
  • 最后修改日期:2025-03-10
  • 录用日期:2025-03-11
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