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渗透压对眼部细胞影响的研究进展
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作者单位:

生物力学与力生物学教育部重点实验室，国家医学攻关(医工结合方向)高端医疗装备与器械产教融合创新平台，北京航空航天大学生物与医学工程学院

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R 318. 01??


Research Progress of the Effects of Osmotic Pressure on Ocular Cells
Author:
  • YAO Feifei 1,2

    YAO Feifei

    Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University
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  • JI Jing 1,2

    JI Jing

    Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University
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  • FAN Yubo 1,2

    FAN Yubo

    Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University
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Affiliation:

1.Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education;2.National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University

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    摘要:

    渗透压是维持细胞稳态的重要内环境因素之一,渗透压变化会影响细胞内的水分和溶质平衡,进而影响细胞的核心功能。在视觉器官中,泪液、房水等内环境渗透压的稳定对于维持角膜上皮细胞、小梁网细胞等的形态和功能具有重要意义。近年来的研究表明,渗透压可调控眼部细胞的活性、炎症反应以及屏障功能。深入研究渗透压对眼部细胞的影响对于理解发病机制、探索新的眼病治疗策略至关重要。本文主要介绍了眼内的渗透压环境及其对眼部细胞的影响及相关机制,并探讨其在眼病治疗中的潜在应用。

    Abstract:

    Osmotic pressure is a critical internal environmental factor that maintains cellular homeostasis. Alterations in osmotic pressure can disrupt the equilibrium of water and solutes within cells, thereby impacting their core functions. In the visual organ, the stability of the osmotic pressure within the internal environment, specifically in substances like tear fluid and aqueous humor, holds paramount significance for sustaining the morphology and functionality of corneal epithelial cells, trabecular meshwork cells, among others. Recent research findings have indicated that osmotic pressure serves as a crucial regulator in modulating the activity levels, inflammatory responses, and barrier functions of ocular cells. A comprehensive investigation into the effects of osmotic pressure on ocular cells is essential for understanding the pathogenesis of ocular diseases and exploring novel therapeutic strategies. This review provides an overview of the ocular osmotic pressure environment, its effects on ocular cells,

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  • 收稿日期:2025-01-15
  • 最后修改日期:2025-03-24
  • 录用日期:2025-03-25
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