老年女性髋部骨折肌肉组织变化与骨密度的相关性分析
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上海市虹口区卫健委重大医学课题及虹口区区科委课题(虹卫2201-06),虹口区卫健委医学科研课题(2202-30)


Correlation Analysis of Muscle Tissue Changes and Bone Mineral Density in Elderly Women with Hip Fracture
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    目的 考虑到肌肉通过力学对骨量变化的影响,调查分析老年髋部骨折女性肌肉组织变化与骨密度(bone mineral density, BMD)之间的关系。方法 选取79例老年髋部骨折女性作为骨折组,45例体检人员为对照组,分析全身肌肉含量、全身脂肪含量、躯干肌肉含量、躯干脂肪含量、上肢肌肉含量、上肢脂肪含量、下肢肌肉含量、下肢脂肪含量,以及腰椎L1~4、股骨颈、髋关节及全身BMD。结果 骨折组老年女性中全身、上肢、下肢肌肉含量及脂肪含量、躯干脂肪含量、骨骼肌指数(skeletal muscle index,SMI)和全身BMD显著低于对照组(P<0.05)。骨折组老年女性肌少症检出率明显增高。粗隆间骨折女性患侧股骨颈BMD明显低于健侧。Logistic回归分析发现,骨折组人群SMI与年龄呈负相关,与体质量指数(body mass index, BMI)、股骨颈及全身BMD呈正相关。结论 老年髋部骨折女性肌少症检出率明显增加,其SMI和股骨颈及全身BMD显著相关,在老年人群骨质疏松性骨折防治中应高度重视肌少症。

    Abstract:

    Objective To investigate the correlation between the change of muscle tissues and bone mineral density (BMD) in elderly women with hip fracture, with consideration of the impact of muscle mechanics on bone mass changes. Methods A total of 79 elderly patients with hip fracture were selected as the fracture group, and 45 physical examination personnel as the control group. Analyze the total muscle mass, total body fat, trunk muscle mass, trunk fat mass, arm muscle mass, arm fat mass, leg muscle mass, leg fat mass, as well as BMD at the lumbar spine (L1-4), femoral neck, hip joint, and whole body. Results Muscle content and fat content of the whole body, upper limb and lower limb, fat content of the trunk, relative skeletal muscle index (SMI) and BMD of the whole body in fracture group were significantly lower than those in control group (P<0.05). The incidence rate of sarcopenia for elderly women in fracture group was higher than that in control group. BMD of femoral neck of the affected side was significantly lower than that of the intact side in women with intertrochanteric fractures. Logistic regression analysis found that SMI in elderly women with hip fracture was negatively correlated with age, and positively correlated with body mass index (BMI), BMD of the femoral neck and whole body. Conclusions The rate of sarcopenia was significantly higher in elderly patients with hip fracture, and SMI was closely related to BMD of the femoral neck and whole body. Therefore, sarcopenia should be highly emphasized in the prevention and treatment of osteoporotic fracture in elderly people.

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裴文江,徐文停,穆培,王宇轩,茅超勇,陈健.老年女性髋部骨折肌肉组织变化与骨密度的相关性分析[J].医用生物力学,2025,40(1):113-117

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  • 收稿日期:2024-10-09
  • 最后修改日期:2024-10-25
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  • 在线发布日期: 2025-02-26
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