Objective To design and verify an implantable dialysis port that makes the central venous catheter no longer placed on the body surface, and to study the effect of the structural design of the central venous catheter on its performance. Methods The feasibility of the dialysis port was verified by flow and pressure experiments. Four representative catheter structures were analyzed by finite element method. The recirculation rate, flow rate pressure ratio and proportion of indwelling particles were recorded, and the performance differences were analyzed. An experimental platform was built to verify the simulation conclusion, and the fluid flow direction of the arteriovenous cavity was quantified by the salinity measurement method. Results The dialysis port can reach the flow requirement of 300 mL / min under the pressure of 45 kPa. The recirculation rate of the measured central venous catheter was between 10.7 % and 23.5 %, and the residual value of heparin was between 2.3 % and 2.8 %. The performance of the catheter with bundle mouth, positive position and side hole structure was better. Conclusions Implantable dialysis port has the possibility to cooperate with central venous catheter to establish a new way of vascular access. The structure of the central venous catheter should adopt the design of the bundle mouth, the positive position and the side hole, which has better recirculation rate and heparin locking performance with low flow rate pressure ratio. The results of this study can provide theoretical and experimental basis for the structural design and clinical selection of central venous catheter.