Objective: This numerical simulation study aims to explore the impact of different moving patterns during the dip-coating process on the thickness distribution of polymer heart valves. Methods: Numerical simulation of the dip-coating process of polymer artificial heart valves based on the volume of fluid (VOF) multiphase flow model, eulerian wall-film (EWF) model, and dynamic mesh technology. The study focused on the dipping liquid flow behavior and thickness distribution under three type of moving patterns—vertical, horizontal, and circular, meanwhile each pattern undergoing rotation as well. For each valve leaflet, thickness data were extracted from seven identical test points, and the coefficient of variation (k_t) was calculated to assess the uniformity of the liquid film thickness. A lower k_t value indicates better thickness uniformity. Since the vertical and horizontal patterns involve fewer motion planes, limiting optimization ways, the circular pattern (45°) was selected as the basis for further numerical simulations with adjusted parameters. Results: The results showed that the peak k_t for the vertical pattern was 0.4613. The horizontal pattern had the least impact on non-uniformity, with a k_t value of 0.4613. In the circular pattern, the k_t decreased as the angle increased, with k_t values of 0.4575, 0.2728, and 0.2556 for 30°, 45°, and 60°, respectively. After adjusting parameters in the circular pattern (45°), the k_t decreased to 0.0525. Conclusion: This study used a numerical simulation approach to predict the distribution of polymeric liquids on the irregular surfaces of heart valves, analyzing the impact of various moving pattern on the liquid film distribution during the dip-coating process. The findings provide a technical way and theoretical basis for optimizing the liquid film thickness distribution of valves.