水凝胶是近年来生物医学领域的重要方向，其生物相容性、生物降解性和生物力学特性使其成为皮肤创面临床治疗的理想材料，具有重要的研究和临床应用价值。作为一种拥有诸多独特生物力学形状的高含水量的三维网络结构高分子材料，水凝胶的诸多力学特性具备应用于皮肤创面的潜力，如弹性、黏弹性、动态刚度及黏附性在人为调节后不仅可以保护创面，而且有助于模拟生物组织在愈合过程中的力学微环境，进而调控细胞的功能与行为，以达到促进细胞再生、强化组织修复与功能恢复的目的。同时，皮肤创面愈合的生物力学机制复杂，水凝胶用于皮肤创面的临床治疗还存在诸多挑战，未来的研究将进一步聚焦于生物力学性质在皮肤创面愈合中作用机制的研究。总之，以其独特的力学性质，水凝胶有望被更广泛地应用于皮肤创面的临床治疗中。本文总结了近年来关于水凝胶生物力学特性，包括调节机制及其应用于临床促皮肤创面修复的研究进展，强调了研究这些特性对于组织工程支架材料设计的重要性，并对力学调节创面愈合的设计、使用和临床转化进行了展望。

Hydrogels are an important direction in the field of biomedicine in recent years. Their biocompatibility, biodegradability and biomechanical properties make them ideal materials for the clinical treatment of skin wounds, and they have important research and clinical application value. As a high water content three-dimensional network structure polymer material with many unique biomechanical shapes, hydrogel has the potential to be applied to skin wounds with many mechanical properties, such as elasticity, viscoelasticity, dynamic stiffness and adhesion, which can not only protect the wound surface after artificial adjustment, but also help to simulate the mechanical microenvironment of biological tissues during healing. Then the function and behavior of cells are regulated to promote cell regeneration, strengthen tissue repair and functional recovery. At the same time, the biomechanical mechanism of skin wound healing is complex, and there are still many challenges in the clinical treatment of skin wounds with hydrogels. Future studies will further focus on the mechanism of biomechanical properties in skin wound healing. In conclusion, hydrogels are expected to be more widely used in the clinical treatment of skin wounds due to their unique mechanical properties. In this paper, we summarized recent research progress on biomechanical properties of hydrogels, including regulatory mechanisms and their clinical application in promoting skin wound repair, emphasized the importance of studying these properties for the design of tissue engineering scaffold materials, and prospeced the design, use and clinical transformation of mechanically regulated wound healing.