发育性髋关节发育不良的软骨下骨血管形成对骨显微结构的影响
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1.上海交通大学医学院附属第六人民医院骨科;2.复旦大学附属中山医院内分泌科;3.上海交通大学医学院附属第六人民医院运动医学科

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Influence of subchondral bone vascularisation on bone microstructure in developmental hip dysplasia
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1.Department of Orthopedic Surgery, Shanghai Sixth People'2.'3.s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine;4.Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University;5.Department of Sports Medicine, Shanghai Sixth People'

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    摘要:

    目的 研究发育性髋关节发育不良(developmental dysplasia of the hip, DDH)力学负荷异常对软骨下骨的骨显微结构和骨血管的影响,以及骨显微结构和骨血管之间的相关性。方法 使用襁褓法构建新生大鼠DDH模型,对股骨头的关节软骨和软骨下骨进行苏木素-伊红染色、番红固绿染色和免疫组化染色等组织学染色,对软骨下骨进行显微计算机断层扫描(Micro-CT)分析骨显微结构。 结果 DDH大鼠出现关节软骨退变,同时伴有软骨下骨的骨显微结构恶化、骨形成减少和血管形成增多,且软骨下骨的血管形成水平与骨显微结构恶化程度呈正相关。结论 DDH力学负荷异常导致关节软骨出现退变,软骨下骨的血管形成增多,软骨下骨的骨显微结构恶化,相关性分析揭示了软骨下骨的血管异常形成可能是造成骨显微结构恶化、DDH进展的重要原因。本研究为探究DDH的发生发展提供了新的研究方向。

    Abstract:

    Objective To study the effects of abnormal mechanical load in developmental dysplasia of the hip (DDH) on the bone microstructure and blood vessels of the subchondral bone, and the correlation between the bone microstructure and blood vessels. Methods A newborn rat DDH model was constructed using the swaddling method, and histological staining such as hematoxylin-eosin staining, safranin-fast green staining, and immunohistochemical staining were performed on the articular cartilage and subchondral bone of the femoral head. The bone microstructure of the subchondral bone was analyzed by micro-computed tomography (Micro-CT). Results DDH rats showed degeneration of articular cartilage, accompanied by deterioration of the bone microstructure of the subchondral bone, decreased bone formation, and increased vascular formation. The level of vascular formation in the subchondral bone was positively correlated with the degree of deterioration of the bone microstructure. Conclusion Abnormal mechanical load in DDH leads to degeneration of articular cartilage, increased vascular formation in the subchondral bone, and deterioration of the bone microstructure of the subchondral bone. The correlation analysis reveals that abnormal vascular formation in the subchondral bone may be an important reason for the deterioration of the bone microstructure and the progression of DDH. This study provides a new research direction to explore the development of DDH.

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  • 收稿日期:2024-05-07
  • 最后修改日期:2024-07-08
  • 录用日期:2024-07-16
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