Objective: Study the effect of enhanced external counter pulsation （EECP） on typical coronary artery diseases. Methods: Lumped parameter models were established to simulate coronary conduit arteries and coronary microcirculation under normal physiological condition, one-vessel lesion, three-vessel lesions and microcirculation angina. EECP interference was simulated on these models. Results: For models under normal condition, under three coronary diseases and EECP interference simulation, the blood flow patterns were in consistent with reported experiment data. EECP improved coronary blood flow under all three coronary diseases. For one-vessel lesion, EECP could recover LMCA blood flow to normal level as the degree of stenosis was lower than 80%-85%. For three-vessel lesions, EECP would be ineffective if one of the three vessels has a stenosis over 90%. For microcirculation angina, EECP would be effective as MBF>1.03 mL/（min·g） and CFR>1.64. Conclusions: The modeling of coronary circulation under EECP interference was accurate. And we obtained useful simulation data which might inspire new clinical studies about EECP on coronary diseases.