目的 探究比较不同涂布方法对复杂柔性硅胶血管仿体制作质量的影响。 方法 基于个性化前交通动脉瘤模型,采用喷涂和旋涂两种方法,制作多例硅胶血管仿体,定量比较两种方法在制作同一血管结构时的厚度增长、周向均匀以及透光性等指标。 结果 旋涂法在血管大曲率、变径位置和直管位置处的厚度控制以及厚度均匀性占优,且具有较好的光性和表面光滑性。 旋涂法厚度相对偏差较喷涂法分别降低 8. 9% 、10. 8% 和 16. 9% 。 结论 现阶段旋涂法在制作硅胶仿体模型时较喷涂法具有厚度均匀性优势和透光性优势,在大血管流体力学体外实验领域具有十分可期的应用前景。
Objective To investigate the effect of different coating methods on production quality of complex and flexible silicone vascular replicas. Methods Based on models of anterior communicating artery aneurysms, several patient-specific models were made by using spray-coating method and brush-spin-coating method respectively, and two methods for making the same vascular structure were quantitatively compared in terms of thickness growth, circumferential uniformity and light transmittance. Results Brush-spin-coating method was better than spray-coating method in the thickness control and coating uniformity for fabrication of vessels with large curvature, variable diameter and straight tube, and the model had preferably light transmittance and surface smoothness. The relative deviation of thickness by brush-spin-coating method was decreased by 8. 9% , 10. 8% and 16. 9% respectively compared with spray-coating method. Conclusions At present stage, the brush-spincoating method has the advantage of thickness uniformity and light transmittance over the spray-coating method in making silicone phantoms, and it has promising application prospects in fluid mechanics field of in vitro experiment on large vessels.
尹 凯,曹 禛,迟青卓,王明亮,母立众,贺 缨.涂布方式对柔性硅胶血管制作质量的影响[J].医用生物力学,2023,38(1):135-141复制