1.中国科学技术大学 生命科学与医学部;2.中国科学院 苏州生物医学工程技术研究所
目的 目前市场上主流眼压测量设备以接触式和刺激性激励为主,使用过程中极易给患者带来不适更有甚者会导致角膜感染,为了解决这一问题,本研究提出了一种超声成像眼压非接触式测量方法。方法 对该方法进行有限元分析与实验验证,得到角膜形变仿真计算结果,制作模拟眼并搭建了眼压测量实验系统,建立了眼压、角膜形变与压力的数学模型并对该模型进行了准确性和重复性验证。结果 实验结果表明：在某一眼压下,角膜的压平直径和顶点位移分别与压力存在幂函数与线性关系；在恒定压力下,压平直径和顶点位移均与眼压存在幂函数关系,可作为眼压测量指标。验证结果显示：通过该方法测得的眼压平均相对误差在8％以下,相对平均偏差在9％以下。结论 该方法测量结果准确,重复性较好。研究结果为眼压的非接触测量提供了一种有效途径,具有较好的应用前景。
Objective Currently, the mainstream intraocular pressure(IOP) measurement devices in the market are contact and irritant, which can easily bring discomfort to patients and even lead to corneal infection during use. To solve this problem, an non-contact measurement method of intraocular pressure based on ultrasound imaging was proposed. Methods The method is verified by finite element analysis and experiment, and the simulation results of corneal deformation are given. A simulated eye was made and an experimental system for measuring IOP was built. A mathematical model of IOP, corneal deformation and pressure was established and its accuracy and repeatability were verified. Results The experiment results show that the flattened diameter and vertex displacement of the cornea have power and linear relationship with pressure under a certain IOP; both flattened diameter and vertex displacement have power relationship with IOP under constant pressure, which can be used as the index of IOP measurement. The verification results indicate that the average relative error of IOP measured by this method is less than 8%, and the relative average deviation is less than 9%. Conclusions The measurement results of the method are accurate and have good repeatability. The results of this study provide an effective way for non-contact measurement of IOP, which has a good application prospect.