负压吸附式角膜夹持器设计与吸附参数仿真研究
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国家自然科学基金项目(51875011)


Design of Corneal Holder Based on Negative Pressure Suction and Simulation of Suction Parameters
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    摘要:

    目的 提出一种通过负压将角膜吸附提升至合适缝合深度的高度后进行缝合的方案,并对吸附参数进行仿 真研究。 方法 根据手术要求,设计负压吸附式角膜夹持器。 建立不同长度、深度及位置的直型伤口角膜的吸附 仿真模型,针对 6 种负压条件,利用流固耦合分析对负压吸附角膜过程进行仿真,求解角膜变形、应力及吸附力。 在 PDMS 薄膜上测量 6 种负压条件所产生的吸附力,并与仿真结果对比分析。 同时在离体猪眼球上进行吸附实 验,评估所设计角膜夹持器的操作安全性。 结果 -70~ -40 kPa 负压下,所有仿真模型角膜最大变形均大于角膜 缝合深度要求的伤口最大提升高度。 最大变形随负压减小而增大。 所有仿真模型角膜最大应力均小于角膜基质 破坏强度(5 MPa)。 吸附力仿真值相对实验值比较吻合。 负压高于-70 kPa 时所设计夹持器进行吸附操作时角膜 未出现破裂。 结论 该角膜夹持器在-70~ -40 kPa 负压下能实现角膜缝合深度要求,且可通过改变负压精确调控 缝合深度,高于-70 kPa 时进行吸附操作不损伤角膜组织。 在该角膜夹持器辅助下,医生可使用直针完成角膜缝合 操作,降低临床操作的难度。

    Abstract:

    Objective To propose a scheme to suture the cornea after sucking and raising the cornea to a height suitable for suturing by negative pressure, and conduct the simulation study on suction parameters. Methods According to surgical requirements, the corneal holder based on negative pressure suction was designed. The simulation models of sucking cornea with straight wound ( different types of length, depth and position) were established, and then the procedure of sucking cornea under 6 negative pressure conditions was simulated by fluid-structure interaction to solve the deformation, corneal stress and suction force. The suction force caused by the holder under 6 negative pressure conditions was measured on the PDMS film and compared with the simulation results. The operating safety of the proposed holder was evaluated by in vitro porcine eye experiment. Results The maximum corneal deformation in all simulation models under negative pressure from - 70 kPa to -40 kPa was greater than the maximum raising height of wound required for corneal suturing depth. The maximum corneal deformation increased with the negative pressure decreasing. The maximum corneal stress of all simulation models was less than the corneal stroma damage strength (5 MPa). The suction force of simulation was in good agreement with the experimental results. No corneal rupture occurred when the holder conducted the sucking operation under negative pressure higher than -70 kPa. Conclusions The corneal holder proposed in this study can meet the required depth in corneal suture surgery within the set negative pressure from - 70 kPa to -40 kPa, and can precisely control the suturing depth by changing the negative pressure. The corneal tissues will not be damaged under negative pressure higher than -70 kPa. With the assistance of the corneal holder, doctors can use a straight needle to conduct corneal suture surgery and reduce the difficulty of clinical operations.

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符志谋,郑 昱,广晨汉,林 闯,刘建军,杨 洋,梁庆丰.负压吸附式角膜夹持器设计与吸附参数仿真研究[J].医用生物力学,2022,37(6):1014-1019

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  • 收稿日期:2022-03-17
  • 最后修改日期:2022-05-02
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  • 在线发布日期: 2022-12-24
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