Three-dimensional ( 3D) printing technology has become the focus of researches in various fields,including 3D scanning anatomical structure or surface, 3D digital reconstruction, computer-aided modeling, STL format conversion, product printing and other steps. Because of its low production cost, high production efficiency, individualized design and other advantages, 3D printing is widely used in various fields of medicine. In recent years, 3D printing technology has been gradually applied in the production of orthopedic orthotics, which plays an important role in the treatment and rehabilitation of joint, trauma and spinal-related diseases. In thisreview, the manufacturing method, classification and application of 3D printed-orthosis were summarized.