Objective To determine mechanical parameter differences in different partitions of parietal bone fragments and their relationship with the thickness. MethodsThe left parietal bones were divided into three partitions, i.e., upper parietal bone (UPB), lateral parietal bone (LPB) and posterior parietal bone (PPB), and the fragments from each partition were intercepted. The ultimate load of the fragments, deformation under ultimate load, bending strength and elastic modulus under ultimate load were detected by quasi-static three-point bending test, and the differences in material mechanical parameters of parietal bones in different partitions were analyzed, as well as the correlation between bone thickness and the parameters above. Results The thickness was as follows: UPB>PPB>LPB (F=21.298, P<0.05). There were significant differences in ultimate load, bending strength and elastic modulus among the UPB (F=7.082), LPB (F=5.206) and PPB (F=7.748, P<0.05). The ultimate load was as follows: UPB>PPB>LPB. The bending strength and elastic modulus were as follows: LPB>PPB>UPB. There were significant differences in deformation between the UPB and the LPB (P<0.05). The ultimate load was positively correlated with the thickness (r=0.683, P<0.05), while the bending strength (r=-0.467) and elastic modulus (r=-0.646) were negatively correlated with the thickness (P<0.05). Conclusions The mechanical parameters and the thickness of materials in different partitions of parietal bone fragments are different. The ultimate load has a positive correlation with the thickness, while the bending strength and elastic modulus have a negative correlation with the thickness.