Objective: To determine the differences of mechanical parameters of bone fragments from different regions of human cadaveric parietal bone and their relationship with thickness. Methods: The parietal bones of human cadavers were divided into three partitions, i.e., left superior parietal, left parietal and left posterior parietal, and the fragments from each partition were intercepted. The ultimate load of the fragments, the deformation under ultimate load, bending strength and elastic modulus under the ultimate load were detected by quasi-static three-point bending test, and the differences in material mechanical parameters of parietal bones from different partitions were analyzed, as well as the correlation between bone thickness and the above parameters. Results There were significant differences in the thickness of the left superior parietal, left parietal and left posterior parietal(F=21.298, P<0.05). The thickness of parietal bone was in the order of left superior parietal > left posterior parietal > left parietal. The differences of ultimate load, bending strength and elastic modulus among the left superior parietal, left parietal and left posterior parietal groups were statistically significant (F values were 7.082, 5.206 and 7.748, respectively, P<0.05). The ultimate load is in the order of left superior parietal > left posterior parietal > left parietal. The deformation under ultimate load of left parietal is obviously higher than that of other two groups. The order of bending strength and elastic modulus was: left parietal > left posterior parietal > left superior parietal. The results of pairwise comparison showed that the difference of deformation under ultimate load was statistically significant between the left superior parietal and left parietal groups (P<0.05). The ultimate load was positively correlated with the thickness (r=0.683, P<0.05), while the bending strength and elastic modulus were negatively correlated with the thickness (r = 0.467 and -0.646, P<0.05, respectively). Conclusion: The mechanical parameters and thickness of materials in different regions of human cadaveric parietal bone are different. The ultimate load has a positive correlation with thickness, while the bending strength and elastic modulus have a negative correlation with thickness.