Cell migration is a basic physiological activity of cells, which not only plays an important role in vascular reconstruction, inflammatory response, tissue development, wound healing, etc., but also is related to the invasion and metastasis of cancer cells. Plectin (499~533kDa) is a macromolecular skeleton protein widely expressed in various tissues and cells. It has important biological functions and participates in many physiological and pathological processes of cells. Plectin can affect migration by regulating the cytoskeleton and through related signaling pathways. This review focuses on the role of plectin in cancer cell migration and its related molecular mechanisms, and provides a theoretical basis to further understand and study the relationship between plectin and cancer cell migration and its targeted intervention.