基于快、慢速加载的单轴拉伸数据识别的角膜生物力学特性的比较
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首都医科大学生物医学工程学院

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R 318.01

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Comparison of corneal biomechanical properties based on the data from uniaxial test with fast vs slow loading
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    摘要:

    目的:利用兔角膜条单轴拉伸实验获得的数据,比较快速与慢速加载速率下确定的角膜生物力学特性参数。 方法:选取15只健康成年兔的角膜进行加载速率为0.1 mm/s和0.02 mm/s的单轴拉伸实验,分别获得应力-应变数据以及应力松弛数据;分别利用粘超弹性模型、1阶Ogden模型和2阶Prony级数模型对加卸载迟滞环曲线、应力-应变曲线、应力松弛曲线进行分析。基于粘超弹性模型拟合快速加卸载迟滞环曲线确定的参数集记为Gvh。拟合慢速加载的应力-应变数据、应力松弛数据的材料参数集记为GOP。利用相关性分析比较Gvh与GOP之间参数的相关性。 结果:对快速加卸载迟滞环数据、慢速加载的应力-应变数据与应力松弛数据的拟合优度R2都大于0.95。Gvh与GOP中6个参数中5个差异明显 (P<0.05),并且两参数组中Ogden模型参数呈正相关。 结论:基于快、慢速加载的单轴拉伸数据识别的角膜生物力学参数具有差异性,理解、解释这些差异,以及如何应用等需要进一步深入研究。

    Abstract:

    Objective: To compare the corneal biomechanical parameters identified from the data of uniaxial test with fast vs slow loading on rabbit corneal strips. Methods: The stress-strain data and stress relaxation data were obtained from uniaxial tensile tests of the corneal strips from 15 healthy adult rabbits at loading rates of 0.1 mm/s and 0.02 mm/s, respectively. A visco-hyperelastic model was applied to analyze the loading and unloading data from the fast stretch tests, where the model parameter set was denoted by Gvh. The first-order Ogden model and second-order Prony series model were used to fit stress-strain data and stress relaxation data from the slow tensile tests, respectively, in which the model parameter set was denoted by GVH. Correlation analysis was used to compare the correlation of parameters between GVH and GOP. Results: All the goodness-of-fits to the 3 data sets were greater than 0.95. There were significant differences in 5 of the 6 parameters between GVH and GOP (P < 0.05), and the Ogden model parameters was positively correlated between the two groups. Conclusions: There are differences in corneal biomechanical parameters identified based on fast and slow loaded uniaxial tensile data. Further research is needed to understand and explain these differences and how to apply them.

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  • 收稿日期:2021-10-12
  • 最后修改日期:2021-11-24
  • 录用日期:2021-11-26
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