With the rapid developmentof computer science and technology, the concept of digital medicine emerges,and digital technique is increasingly used in the field of orthopedics. Finite element analysis（FEA）is one of the powerful and highly effective methods to simulate real experiments, and it is often employed to study the medical issues of biomechanics，biomaterials and surgery simulation etc. In particular, FEA usage in the field of ankle is growing as well. At present, FEA-based biomechanical analysis of foot and ankle has been widely used in the mechanism analysis of diabetic foot, plantar fascia disease, foot and ankle fracture and osteoarthritis. Moreover, it is also used in prosthetic design, surgical simulation, shoe and insole design etc. The FEA clinical applications have significantly enhanced the knowledge of surgeons in the aspect of the foot biomechanics, and leads a new way to investigate the ankle-related diseases. However, FEA studies of hallux valgus are relatively limited. To this end, the purpose of this paper is to summarize the biomechanical FE analysis and modeling of the hallux valgus, secondary flatfoot and metatarsal pain, including current situation of FE clinical applications of the foot and ankle, and present the FE advantages/disadvantages and its future prospects.