Objective To design a new biodegradable intestinal anastomosis stent and explore the relationship between the pressure distance and the biomechanical properties of the anastomosis, so as to provide new ideas and methods for compression anastomosis of intestinal tissues. Methods A compression anastomosis stent was designed for the reconstruction of intestinal tissues, and a finite element model of compression anastomosis of intestinal tissues was established to investigate the relationship between the pressurized distance (2 mm, 1.6 mm, 1.2 mm, 0.8 mm) and the tissue stress of the stent. Results The biomechanical properties of the intestinal anastomosis were best when the applied pressure distance was 1.2 mm, and its maximum tensile strength reached 0.77 MPa; the tear-off force and burst pressure of the tissue were 25.80±1.82 N and 12.30±0.26 kPa respectively. The best intestinal anastomosis was achieved when the tissue was compressed to 60% of the original thickness. Conclusion The biodegradable intestinal stent designed in this paper can successfully achieve the compression anastomosis of intestinal tissue, which provides an important theoretical reference for the development and application of new biodegradable compression anastomosis devices.